Endogenous mediators of growth

Endogenous mediators of growth.

In the present review it is not possible to discuss the effects of the numerous endogenous mediators of growth. What we have attempted to do is to indicate the areas of controversy and the need for further research. In our view, four main questions arise. First, what are the relative contributions of the direct and indirect effects of GH? Indeed, if GH can produce all its effects by local produ...

Endogenous mediators of growth

Growth comprises three separate componcnts; whole-body growth, tissue turnover and repair, and last, the response to external stimuli. Whole-body growth can be divided into changes associated with muscle, skin, viscera and skeleton. Because of our interest in bone metabolism the present review will concentratc on the processes associated with skeletal growth, turnover, and response to external ...

Further comparisons of endogenous pyrogens and leukocytic endogenous mediators.

It was recently shown (Murphy et al., Infect. Immun. 34:177-183), that rabbit macrophages produce two biochemically and immunologically distinct endogenous pyrogens. One of these has or copurifies with substances having a molecular weight of 13,000 and a pI of 7.3. This protein was produced by blood monocytes or inflammatory cells elicited in 16-h rabbit peritoneal exudates. These acute periton...

Endogenous lipid mediators in the resolution of airway inflammation.

Acute inflammation in the lung is fundamentally important to host defence, but chronic or excessive inflammation leads to several common respiratory diseases, including asthma and acute respiratory distress syndrome. The resolution of inflammation is an active process. In health, events at the onset of acute inflammation establish biosynthetic circuits for specific chemical mediators that later...

Endogenous growth promotors and inhibitors in tahiti lime